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pentobarbital will reduce the level or impact of pioglitazone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unfamiliar.pentobarbital will lessen the level or influence of larotrectinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.buprenorphine subdermal implant and pentobarbital both improve sedation.